Drug Interactions With Dextroamphetamine (Cont.)

 
Lithium (Eskalith, Lithobid, Lithonate)
Taking dextroamphetamine and lithium together can decrease the effectiveness of dextroamphetamine. Your healthcare provider may need to adjust your dose of these drugs.
 
Medications for High Blood Pressure
Taking dextroamphetamine and a high blood pressure medication together can decrease the effectiveness of the blood pressure medication. Your healthcare provider may need to adjust your dose of these drugs.
 
Meperidine (Demerol)
Taking dextroamphetamine and meperidine together can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these drugs.
 
Methenamine (Hiprex, Urex)
Taking dextroamphetamine and methenamine together can decrease the amount of dextroamphetamine in the blood, possibly making it less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
MAO Inhibitors
Taking dextroamphetamine and MAO inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take dextroamphetamine if you have taken an MAO inhibitor in the past two weeks.
 
Norepinephrine (Levophed)
Taking dextroamphetamine and norepinephrine together can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to adjust your dose of these drugs.
 
Phenobarbital (Luminal)
Taking dextroamphetamine and phenobarbital together can cause phenobarbital to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenobarbital to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenobarbital. Your healthcare provider may need to adjust your dose of these drugs.
(Drug Interactions With Dextroamphetamine Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;