Drug Interactions With Dextroamphetamine (Cont.)

 
Phenytoin (Dilantin)
Taking dextroamphetamine and phenytoin together can cause phenytoin to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenytoin to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenytoin. Your healthcare provider may need to adjust your dose of these drugs.
 
Propoxyphene (Darvocet, Darvon)
Taking dextroamphetamine and very high doses of propoxyphene together can cause life-threatening side effects, such as seizures. Do not take dextroamphetamine and very high doses of propoxyphene together unless specifically told to do so by your healthcare provider.
 
Reserpine
Taking dextroamphetamine and reserpine together can cause a decrease in the amount of dextroamphetamine in the blood, possibly making it less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
Tricyclic Antidepressants
Taking dextroamphetamine and tricyclic antidepressants together can change the way the brain reacts to dextroamphetamine, possibly causing side effects. Your healthcare provider may need to adjust your dose of these drugs.
 

Final Thoughts on Drug Interactions With Dextroamphetamine

It is possible that not every dextroamphetamine drug interaction was discussed in this article. Therefore, you should talk with your healthcare provider about the specific drug interactions with dextroamphetamine that may apply to you.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;