Sleep Home > Drug Interactions With Eszopiclone

If you are taking eszopiclone with other drugs, interactions could occur, possibly increasing the drug levels in your body or leading to side effects. Some of the medications that may cause drug interactions with eszopiclone include certain anticonvulsants, protease inhibitors, rifamycin antibiotics, and diclofenac.

Drug Interactions With Eszopiclone: An Overview

Eszopiclone (Lunesta®) can potentially interact with many drugs. Some of the drugs that may lead to eszopiclone drug interactions include:
 
  • Alcohol
     
  • Certain antibiotics or antifungals, including:
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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