Sleep Home > Drug Interactions With Methylphenidate

Before starting methylphenidate, tell your healthcare provider about all medicines you may be taking, because many can cause drug interactions with methylphenidate. When interactions occur, the drug levels in your system may be increased and side effects may develop, including high blood pressure and increased heart rate. Medications that may potentially lead to drug interactions with methylphenidate include tricyclic antidepressants, pressors, warfarin, and monoamine oxidase inhibitors.

Drug Interactions With Methylphenidate: An Overview

Methylphenidate hydrochloride (Ritalin®) can potentially interact with many other medicines. Some of the medications that may lead to drug interactions with methylphenidate include:
  • Monoamine oxidase inhibitors (MAOIs), including:




    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)




Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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