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When monoamine oxidase inhibitors, rifamycin antibiotics, or estrogen-containing medications are taken with Provigil, drug interactions may occur. These interactions can increase or decrease drug levels in your blood, which can reduce the effectiveness of the medicines or increase your risk of side effects. Other medications that may lead to Provigil drug interactions include propranolol, tricyclic antidepressants, and certain protease inhibitors.

Provigil Drug Interactions: An Overview

Provigil® (modafinil) can potentially interact with several other medicines. Some of the medicines that may lead to Provigil drug interactions include:
 
  • Certain antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
 
 
  • Propranolol (Inderal®, Inderal® LA)
  • Rifamycin antibiotics, such as rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Seizure medications
  • Some protease inhibitors, such as:
 
 
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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