Sleep Home > Ramelteon Side Effects

Dizziness, drowsiness, and fatigue are some of the more common side effects seen with ramelteon. Side effects of the medication are generally considered minor and do not require medical attention. However, if you develop any serious ramelteon side effects such as depression, worsening insomnia, or suicidal thoughts, be sure to contact your healthcare provider immediately.

Side Effects of Ramelteon: An Introduction

As with any medicine, there are possible side effects with ramelteon (Rozerem®). However, not everyone who takes ramelteon will experience side effects. In fact, most people tolerate the sleep medicine well. When ramelteon side effects do occur, they are generally minor and either require no treatment or can easily be treated by you or your healthcare provider.
(The side effects with ramelteon discussed below are not a complete list of side effects reported with this drug. Your healthcare provider can discuss a more complete list of ramelteon side effects with you.)

Common Side Effects With Ramelteon

Ramelteon has been studied extensively in clinical trials, with many people having been evaluated. In these studies, side effects occurring in the group of people taking the drug are always documented and compared to the side effects that occur in a similar group of people not taking the medicine. Based on these studies, the most common side effects of ramelteon include:
  • Drowsiness -- up to 5 percent
  • Dizziness -- up to 5 percent
  • Fatigue -- up to 4 percent
  • Nausea -- up to 3 percent
  • Worsened insomnia -- up to 3 percent
  • Upper respiratory tract infections (such as the common cold) -- up to 3 percent
  • Muscle pain -- up to 2 percent
  • Depression -- up to 2 percent (see Rozerem and Depression)
  • Taste changes -- up to 2 percent
  • Influenza (the flu) -- up to 1 percent.
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Last reviewed by: Kristi Monson, PharmD;
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