Sleep Home > Drug Interactions With Zolpidem
Certain drug interactions with Zolpidem may cause your body to metabolize the medicines differently than intended and increase the amount of zolpidem in your system. Some medications that may possibly cause an interaction include rifampin, chlorpromazine, sertraline, and flumazenil. Because some drug interactions with zolpidem can be dangerous, it is important to let your healthcare provider know if you are taking other medications.
This article refers to short-acting zolpidem tablets (Ambien®). For other forms, see Edluar Drug Interactions or Intermezzo Drug Interactions (for zolpidem sublingual tablets), Zolpimist Drug Interactions (for zolpidem oral spray), or Ambien CR Drug Interactions (for zolpidem extended-release tablets).
Zolpidem (Ambien) has a number of other medicines that it can potentially interact with. Some possible zolpidem drug interactions can include:
- Imipramine (Tofranil®)
- Chlorpromazine (Thor-Prom®, Thorazine®)
- Sertraline (Zoloft®)
- Rifampin (Rifadin®, Rimactane®)
- Flumazenil (Romazicon®)
- Other medicines that act on the brain.
When imipramine and zolpidem are taken at the same time, there may be an additional decrease in awareness in patients. To avoid this possible drug interaction, it is recommended that a person discuss alternatives with his or her healthcare provider prior to taking zolpidem.