Interactions With Methylphenidate Explained
The following sections explain in detail the potentially negative interactions that can occur when
methylphenidate is combined with any of the drugs listed above.
Clonidine
Taking methylphenidate with clonidine can increase your risk of serious side effects. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
Monoamine Oxidase Inhibitors
If methylphenidate and MAOIs are taken together, this can cause life-threatening side effects, such as very
high blood pressure. Do not take the medications together unless your healthcare provider specifically tells you to do so. Do not take methylphenidate if you have taken an MAOI within the past two weeks.
Pressors
Combining methylphenidate and pressors can cause an increase in side effects, particularly increased
blood pressure and heart rate. Depending on your particular situation, your healthcare provider may need to monitor your heart rate and blood pressure closely and adjust your dose of these drugs, if necessary.
Seizure Medications
Taking methylphenidate with
seizure medications can increase the amount of
seizure medication in your blood, perhaps increasing your risk of side effects. To prevent this interaction from occurring, your healthcare provider may need to decrease your dose of the seizure medication.
Tricyclic Antidepressants
If methylphenidate and
tricyclic antidepressants are taken together, this can increase the amount of
antidepressant in your blood, which may increase your risk of side effects. Your healthcare provider may need to decrease your dose of the antidepressant to prevent this interaction from occurring.
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