Nuvigil Drug Interactions

Nuvigil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Nuvigil is combined with any of the drugs listed above.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Nuvigil may decrease the level of cyclosporine in your blood, perhaps making it less effective. If you take these two medications together, your healthcare provider may need to measure the level of cyclosporine in your blood and adjust your dose as necessary.
 
Diazepam (Valium)
Nuvigil may increase the level of diazepam in your blood, possibly increasing the risk of side effects. Your healthcare provider may need to lower the dose of diazepam if you are taking both of these medications.
 
Estrogen-Containing Medications
Nuvigil can decrease the level of estrogen medications in the blood. This can be especially important for women using birth control pills, patches, or rings, as these forms of birth control may be less effective if combined with Nuvigil. You should use an alternative or backup form of contraception (such as condoms) while taking Nuvigil and for at least one month after starting it.
 
Many Antibiotics or Antifungals
Combining Nuvigil with certain antibiotics or antifungals may increase the level of Nuvigil in your blood. Your healthcare provider may recommend that you take a lower Nuvigil dosage as a result. Check with your healthcare provider before taking Nuvigil with any of these medications.
 
Monoamine Oxidase Inhibitors (MAOIs)
It is not known if it is safe to take Nuvigil with an MAOI. Since medications similar to Nuvigil interact dangerously with MAOIs, it is a good idea to avoid taking Nuvigil with an MAOI until more information is available.

Nuvigil Drug Information

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