Nuvigil Drug Interactions

When certain medications (such as warfarin or cyclosporine) are taken with Nuvigil, drug interactions may occur. These interactions could either reduce the effectiveness of the medicines or increase your risk for developing side effects. Other medications that may lead to negative Nuvigil drug interactions include tricyclic antidepressants, monoamine oxidase inhibitors, rifamycin antibiotics, and some protease inhibitors.

 

Nuvigil Drug Interactions: An Overview

Nuvigil™ (armodafinil) can potentially interact with several other medicines. Some of the medicines that may lead to Nuvigil drug interactions include:
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Diazepam (Valium®)
  • Estrogen-containing medications, including birth control pills, patches, or rings
  • Many antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Propranolol (Inderal®, Inderal® LA)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Seizure medications
  • Some protease inhibitors, such as:
 
 
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Nuvigil Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;