Provigil Drug Interactions (Cont.)

Provigil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Provigil is combined with any of the drugs listed above.
 
Certain Antibiotics or Antifungals
Combining Provigil with certain antibiotics or antifungals may increase the level of Provigil in your blood. Your healthcare provider may recommend that you take a lower Provigil dosage to prevent this. Check with your healthcare provider before taking Provigil with any of these medications.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Provigil may decrease the level of cyclosporine in your blood, potentially making it less effective. If you take these two medications together, your healthcare provider may need to measure the level of cyclosporine in your blood and adjust your dose as necessary.
 
Diazepam (Valium)
Provigil may increase the level of diazepam in your blood, possibly increasing the risk of side effects. Your healthcare provider may need to lower the dose of diazepam if you are taking both of these medications.
 
Estrogen-Containing Medications
Provigil can decrease the level of estrogen medications in the blood. This can be especially important for women taking birth control pills, patches, or rings, as these forms of birth control may be less effective if combined with Provigil. You should use an alternative or backup form of contraception (such as condoms) while taking Provigil and for at least one month after starting the drug.
 
Monoamine Oxidase Inhibitors (MAOIs)
It is not known if it is safe to take Provigil with an MAOI. Since medications similar to Provigil interact dangerously with MAOIs, it is probably a good idea to avoid taking Provigil with an MAOI until more information is available.
 
Propranolol (Inderal, Inderal LA)
Taking propranolol with Provigil can increase the level of propranolol in your blood, possibly increasing the chance of side effects. Check with your healthcare provider before taking these two medications together.
(Provigil Drug Interactions Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;