Provigil Drug Interactions

Rifamycin Antibiotics
Rifamycin antibiotics may decrease the level of Provigil in your blood, perhaps making it less effective. Contact your healthcare provider if you notice that Provigil seems to be less effective since starting a rifamycin antibiotic.
 
Seizure Medications
Check with your healthcare provider before taking Provigil with any seizure medications. Some seizure medications may decrease the level of Provigil in your blood, and Provigil may increase the level of some seizure medications in your blood.
 
Some Protease Inhibitors
Some protease inhibitors may increase the level of Provigil in your blood, possibly increasing your risk of Provigil side effects. Check with your healthcare provider before taking Provigil with a protease inhibitor.
 
Tricyclic Antidepressants
Combining a tricyclic antidepressant with Provigil may increase the level of the antidepressant in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower the dose of your tricyclic antidepressant to prevent this drug interaction from occurring.
 
Warfarin (Coumadin, Jantoven)
Provigil may interact with warfarin. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary, especially when you start or stop taking Provigil.
 

Final Thoughts on Provigil Drug Interactions

It is possible that not every drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific Provigil drug interactions that may apply to you.
 

Provigil Medication Information

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