Provigil Drug Interactions

When monoamine oxidase inhibitors, rifamycin antibiotics, or estrogen-containing medications are taken with Provigil, drug interactions may occur. These interactions can increase or decrease drug levels in your blood, which can reduce the effectiveness of the medicines or increase your risk of side effects. Other medications that may lead to Provigil drug interactions include propranolol, tricyclic antidepressants, and certain protease inhibitors.

• Certain antibiotics or antifungals, such as:

• Clarithromycin (Biaxin^®)
• Erythromycin (Ery-Tab^®)
• Isoniazid (Nydrazid^®)
• Itraconazole (Sporanox^®)
• Ketoconazole (Nizoral^®)
• Miconazole
• Telithromycin (Ketek^®)

• Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
• Diazepam (Valium^®)
• Estrogen-containing medications, including birth control pills, patches, or rings
• Monoamine oxidase inhibitors (MAOIs), such as:

• Isocarboxazid (Marplan^®)
• Phenelzine (Nardil^®)
• Rasagiline (Azilect^®)
• Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)
• Tranylcypromine (Parnate^®)

• Propranolol (Inderal^®, Inderal^® LA)
• Rifamycin antibiotics, such as rifabutin (Mycobutin^®), rifampin (Rifadin^®), and rifapentine (Priftin^®)
• Seizure medications
• Some protease inhibitors, such as:

• Amprenavir (Agenerase^®)
• Atazanavir (Reyataz^®)
• Fosamprenavir (Lexiva^®)
• Indinavir (Crixivan^®)
• Nelfinavir (Viracept^®)
• Ritonavir (Norvir^®)
• Saquinavir (Invirase^®)

• Tricyclic antidepressants, such as:

• Amitriptyline (Elavil^®)
• Amoxapine (Asendin^®)
• Clomipramine (Anafranil^®)
• Desipramine (Norpramin^®)
• Doxepin (Sinequan^®, Silenor^®) 
• Imipramine (Tofranil^®, Tofranil PM^®)
• Maprotiline (Ludiomil^®)
• Nortriptyline (Pamelor^®)
• Protriptyline (Vivactil^®)
• Trimipramine (Surmontil^®)

• Warfarin (Coumadin^®, Jantoven^®).