Drug Interactions With Zaleplon (Cont.)

Zaleplon Interactions Explained

 
Alcohol
When alcohol and zaleplon are taken at the same time, zaleplon may increase the effects of the alcohol. It is, therefore, recommended that you do not drink alcohol when taking zaleplon (see Sonata and Alcohol).
 
Certain Antibiotics or Antifungals
Taking zaleplon with certain antibiotics or antifungals can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these medications together.
 
Certain Anticonvulsants
Taking zaleplon with certain anticonvulsants can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Cimetidine (Tagamet)
Taking zaleplon with cimetidine can substantially increase the level of zaleplon in your blood. If you are taking cimetidine, you should be started on a lower dose of zaleplon (5 mg before bedtime).
 
Delavirdine (Rescriptor)
Taking zaleplon with delavirdine can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Diclofenac (Cataflam, Voltaren)
Taking zaleplon with diclofenac can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Imatinib (Gleevec)
Taking zaleplon with imatinib can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
(Drug Interactions With Zaleplon Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;