Drug Interactions With Zaleplon (Cont.)

 
Imipramine (Tofranil)
Taking zaleplon with imipramine can increase your risks of developing side effects (especially drowsiness). Your healthcare provider may need to adjust your dose of these medications.
 
Nefazodone (Serzone)
Taking zaleplon with nefazodone can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Nevirapine (Viramune)
Taking zaleplon with nevirapine can decrease the level of zaleplon in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Nicardipine (Cardene)
Taking zaleplon with nicardipine can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Promethazine (Phenergan, Promethagan)
Taking zaleplon with promethazine can increase the level of zaleplon in your blood, increasing your chance of developing side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Protease Inhibitors
Taking zaleplon with protease inhibitors can increase the level of zaleplon in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these medications together.
 
Rifamycin Antibiotics
Taking zaleplon with rifamycin antibiotics can decrease the level of zaleplon in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications.
(Drug Interactions With Zaleplon Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;