Drug Interactions With Zaleplon

Certain antifungals, protease inhibitors, and rifamycin antibiotics can cause drug interactions with zaleplon. Drug interactions can cause a significant increase in zaleplon levels in the blood, which increases the risk of developing side effects. Drug interactions may also occur if the sleep medicine is taken together with alcohol, certain anticonvulsants, or diclofenac.

Zaleplon Drug Interactions: An Overview

Zaleplon (Sonata®) can potentially interact with many drugs. Some of the drugs that may lead to drug interactions with zaleplon include:
 
  • Alcohol
     
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • Thioridazine (Mellaril®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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