Drug Interactions With Zolpidem

Certain drug interactions with Zolpidem may cause your body to metabolize the medicines differently than intended and increase the amount of zolpidem in your system. Some medications that may possibly cause an interaction include rifampin, chlorpromazine, sertraline, and flumazenil. Because some drug interactions with zolpidem can be dangerous, it is important to let your healthcare provider know if you are taking other medications.

 

Drug Interactions With Zolpidem: An Introduction

Zolpidem (Ambien®) has a number of other medicines that it can potentially interact with. Some possible zolpidem drug interactions can include:
 
Imipramine (Tofranil)
When imipramine and zolpidem are taken at the same time, there may be an additional decrease in awareness in patients. To avoid this possible drug interaction, it is recommended that a person discuss alternatives with his or her healthcare provider prior to taking zolpidem.
 
Chlorpromazine (Thor-Prom, Thorazine)
When chlorpromazine and zolpidem are given at the same time, there may be an additional decrease in awareness, mental functioning, and coordination. To avoid this possible drug interaction, it is recommended that a person discuss alternatives with his or her healthcare provider prior to taking zolpidem.
 
Alcohol
When alcohol and zolpidem are taken at the same time, zolpidem increases the effects of the alcohol. It is therefore recommended that you do not drink alcohol when taking zolpidem.
(Drug Interactions With Zolpidem Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;